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2 edition of Prognostic factors for first clinical fracture in patients with primary osteoporosis found in the catalog.

Prognostic factors for first clinical fracture in patients with primary osteoporosis

Olga Gajic-Veljanoski

Prognostic factors for first clinical fracture in patients with primary osteoporosis

analyses of data from the Canadian Database of Osteoporosis and Osteopenia.

by Olga Gajic-Veljanoski

  • 4 Want to read
  • 18 Currently reading

Published .
Written in English


About the Edition

Much research has delineated risk factors for osteoporotic fractures while the clinical course and prognosis of osteoporosis remain unexplored. Using data from the Canadian Database of Osteoporosis and Osteopenia, we examined time-to-first clinical fracture during a 30-month follow-up and prognostic factors for first clinical fracture in an inception cohort of 1142 female and male patients aged 40 years and over, with bone mineral density-diagnosed primary osteoporosis and no history of clinical fracture.The cohort, followed for 27 516 person-months, had a 5.08% cumulative fracture incidence or a fracture rate of 10.9/1000 person-months. The multivariable Cox regression complete case analysis revealed two significant prognostic factors: increasing age (Hazard Ratio (HR) = 1.03, 95% CI: 1.01-1.06) and lack of osteoporosis drug treatment (HR = 3.69, 95% CI: 1.94-7.01). Although slight bias toward informative censoring was detected, sensitivity analyses demonstrated no drastic distortions in the parameter estimates, confirming the findings of the complete case analysis.

The Physical Object
Pagination174 leaves.
Number of Pages174
ID Numbers
Open LibraryOL19217118M
ISBN 100494073136

Osteoporotic or fragility fractures are common and contributing factors are the susceptibility to falls and the underlying osteoporosis. Fractures of the vertebrae, the hip and the distal radius. Importantly, the fractures in this study were clinical fractures (i.e., those known to the individual), thus vertebral fractures would be underestimated; perhaps one‐quarter achieve clinical recognition. 27, A strength of this study is that these women did seek regular medical attention and attended a local primary care doctor.

  The authors attribute poorer outcomes in older patients in part to osteoporosis, which presents challenges to surgical reduction and fixation. In a larger study by Matta of fractures followed for a minimum of 2 years, age was shown to be an independent risk factor for clinical outcome. In patients younger than 40 years of age, 81%. The prevalence of vertebral fracture amongst patients presenting with non-vertebral fractures. Osteoporos. Int. 18(2), — (). Bours SP, van Geel TA, Geusens PP et al. Contributors to secondary osteoporosis and metabolic bone diseases in patients presenting with a clinical fracture. J. Clin. Endocrinol. Metab.

  Hip fracture is a common disease among elderly people,and has a high mortality and ,seldom practice can be done to improve this a long time,whether anesthesia type could influence the prognosis after surgery is l studies have confirmed regional anesthesia may be better for patients for its fewer most studies are .   Osteoporotic fracture patients should adhere to long‐term anti‐osteoporosis therapy under the close guidance of responsible physicians to prevent the occurrence of further fractures. Patients with secondary osteoporosis should receive treatment for predisposing diseases and conditions. 6. Prevention of osteoporotic fractures Risk factors. 1.


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Prognostic factors for first clinical fracture in patients with primary osteoporosis by Olga Gajic-Veljanoski Download PDF EPUB FB2

The purpose of this study was to determine prognostic factors for first clinical fracture in patients with T-score clinical fracture. METHODS: We examined prospectively collected data from 1, patients aged 40 and over in the Canadian Database of Osteoporosis Cited by: 4. Age and drug therapy are key prognostic factors for first clinical fracture in patients with primary osteoporosis August Osteoporosis International 18(8)   Abstract.

Osteoporos Int () – DOI /s ORIGINAL ARTICLE Age and drug therapy are key prognostic factors for first clinical fracture in patients with primary osteoporosis O. Gajic-Veljanoski & R. Sebaldt & A. Davis & D. Tritchler & G. Tomlinson & A. Petrie & J. Adachi & A.

Cheung Received: 21 November /Accepted: 17. Although risk factors for osteoporotic fractures are well-known, it is unclear which factors predict poor prognosis in patients with primary osteoporosis. The purpose of this study was to determine prognostic factors for first clinical fracture in patients with T-score ≤ − and no previous clinical fracture.

We examined prospectively Cited by: 4. You or your first degree relative experiencing a prior low-trauma vertebral body fracture; A bone density screening can be useful in helping certain individuals determine their risk level. Factors that reduce your risk of osteoporosis include impact exercise.

However, 82% of patients reporting fracture had peripheral T scores greater thanand 67% had scores higher than 32 Furthermore, within each diagnostic category (osteoporosis, osteopenia, normal), the presence of multiple clinical risk factors increased patient risk for hip fracture.

One hundred twenty-four patients sustained fractures at the tip or below the femoral prosthesis. The incidence of fracture was % at 5 years and % at 10 years after primary implant.

Patients older than 70 years had a times greater risk of sustaining a subsequent fracture. Age and drug therapy are key prognostic factors for first clinical fracture in patients with primary osteoporosis O. Gajic-Veljanoski, R. Sebaldt, A. Davis. The clinical presentation depends on the type of the fracture.

A patient with a stable vertebral fracture usually presents with dorsal pain of acute onset at the fracture area. 1 The pain decreases with rest and increases with activity.

1 It may radiate anteriorly in a radicular fashion. 1 Depending on the pain and/or resultant deformity the. The individualization of fracture prognosis may also be used to optimize the number needed to treat (NNT). In several randomized clinical trials, the number of patients needed to be treated to reduce one vertebral fracture compared to the untreated group ranged between 8 and For hip fracture, the NNT ranged between 91 and The NNT.

The current study presents the clinical data for 10 patients with a fracture who were diagnosed with COVID pneumonia. Previous investigations have documented that the clinical characteristics of patients with both a fracture and pneumonia were more serious than those of patients with only a fracture.

Osteoporosis is the most common metabolic bone disorder and affects a large portion of the population. Osteoporosis is defined as a decrease in bone mass, specifically bone mineral density.

According to the World Health Organization (WHO), a person has osteoporosis if their bone mineral density is standard deviations below that of a normal 25 year-old person or if they have a sustained a.

To assess the need for a fracture prevention program, the primary aim of this study was to estimate the prevalence of osteoporosis in patients treated for fragility fractures at Aarhus University.

However, patients with T-scores above − may still be at high risk of fracture. It has been estimated that over 50% of patients with hip fractures and 35% with vertebral fractures have a T-score above −–38 Hence, a combination of BMD and clinical risk factors for fracture predicts fracture risk better than BMD alone.

fection in a cohort of patients with fractures. Methods: Data on 10 patients with a fracture and COVID were collected from 8 different hospitals located in the Hubei province from January 1,to Febru Analyses of early prognosis were based on clinical outcomes and trends in laboratory results during treatment.

Results: All 10 patients presented with limited activity. The result is an easy-to-use fracture risk assessment tool for family physicians to use with patients of both sexes called FRAX® - Fracture Risk Assessment Tool. The web-based FRAX calculator assesses the ten-year risk of osteoporosis fracture based on specific individual risk factors.

Osteoporotic fractures are a result of osteoporosis, a condition in which the bones become more fragile due to bone deterioration or low bone mass. Bones that are weaker or more fragile are at greater risk for fractures. Fractures occur commonly in the spine. Bone loss can occur without any symptoms, until the fracture actually occurs.

Osteoporosis is the most common type of bone disease. Osteoporosis increases the risk of breaking a bone. About one half of all women over the age of 50 will have a fracture of the hip, wrist, or vertebra (bones of the spine) during their lifetime.

Spine fractures are the most common. Background Non-specific low back pain (NSLBP) is the most prevalent musculoskeletal condition in western countries and is associated with persistent disability and high consumption of health care resources. NSLBP patients first seek primary health care services but the outcomes are often uncertain.

This study aimed to examine the clinical course of the outcomes and to identify prognostic. Treatments for Osteopenia and Osteoporosis in Patients with Breast Carcinoma.

The decision to begin therapy for the prevention or treatment of osteoporosis should take into account several factors, including BMD, the risk of fracture, life expectancy, and the. Purpose: Osteogenesis Imperfecta (OI) is a congenital disorder characterized by multiple fractures and a low bone mineral density (BMD).

In our national OI expertise center for adults, we observed several cases of transient osteoporosis of the hip (TOH). The aim of this study was to report on the prevalence of TOH in adult OI patients, to identify possible additional risk factors and describe.

Such men may have a generally good prognosis, 34 but fracture risk 6 is elevated (as high as 20% fracture risk in 5 years) because of their very. Int J Clin Rheumatol. ;7(1) Overall, when choosing a particular pharmacological agent it should be kept in mind that agents found to decrease vertebral, nonvertebral and hip fractures.